Current clinical practice guidelines recommend specific non-pharmacological therapies as front-line treatments ahead of pharmacological treatment for the management of musculoskeletal pain but guidelines seldom help select the best treatment for a specific patient. Clinical decision-making processes, including patient sub-classification and identification of perpetuating factors, can provide DCs the knowledge to tailor individualized care that will improve patient outcomes. In addition, using the best evidence currently available, the presentation will summarize macro- and micro-nutrient intake, pro- and anti-inflammatory foods, glycemic control and obesity for appropriately selected patients.